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Their cytoplasm cannot be distinguishedfrom the intercellular material (inset). The case fatal-ity rate in ventilated infants with MAS varieswidely in published series (0–37 %) (Cleary andWiswell 1998) and is in?uenced by availabilityof alternative means of ventilation, adjunctivetherapies including nitric oxide and ECMO.Approximately one-quarter to one-third of alldeaths in ventilated infants with a diagnosisof MAS are directly attributable to the pulmo-nary disease, with the remainder in large partcaused by hypoxic-ischaemic encephalopathy(Dargaville and Copnell 2006; Singh et al.2009b; Nolent et al. Upto99.99% M.leprae are killed in 3–7 days by 600mg/day dose. (1996) Case-con-trol study of idiopathic Parkinson’s disease and dietary vitaminE intake.
To prove this in a mouse model,one would have to show further protective benefi ts fromthose achieved with rapamycin alone if resveratrol orpterostilbene were added in late middle age. (1994) Diagnostic and StatisticalManual of Mental Disorders: DSM-IV.
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